Lipid Droplet Binding of Hepatitis C Virus Core Protein Genotype 3

Lipid Droplet Binding of Hepatitis C Virus Core Protein Genotype 3

Background. Hepatitis C virus (HCV) genotype 3 is known to cause steatosis (fatty liver) that is more frequent and severe than other genotypes. We previously identified sequence elements within genotype 3 HCV Core domain 3 that were sufficient for lipid accumulation. Aims. We examined various genotype 3 Core domains for lipid droplet localization and compared the lipid droplet binding regions o...

Specific polymorphisms in hepatitis C virus genotype 3 core protein associated with intracellular lipid accumulation.

BACKGROUND Steatosis is a common histological finding and a poor prognostic indicator in patients with hepatitis C virus (HCV) infection. In HCV genotype 3-infected patients, the etiology of steatosis appears to be closely correlated with unknown viral factors that increase intracellular lipid levels. We hypothesize that specific sequence polymorphisms in HCV genotype 3 core protein may be asso...

Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis.

Steatosis is a frequent complication of hepatitis C virus infection. In mice, this condition is recapitulated by the expression of a single viral protein, the nucleocapsid core. Core localizes to the surface of lipid droplets (LDs) in infected liver cells through a process dependent on host diacylglycerol acyltransferase 1 (DGAT1), an enzyme that synthesizes triglycerides in the endoplasmic ret...

associations among genotype 1b hepatitis c virus core protein, protein kinase r, and signal transducer and activator of transcription 3

Hepatitis C virus core protein, lipid droplets and steatosis.

Lipid droplets are intracellular organelles involved not only in lipid storage but also in cell signalling and the regulation of intracellular vesicular trafficking. Recent basic studies have suggested that interactions between hepatitis C virus (HCV) core protein and lipid droplets are required for the HCV infection cycle. In infected cells, the HCV core protein is associated with the surface ...